Ab-DeliverIN^™

Antibody delivery reagent Ab-DeliverINTM is the first dedicated intracellular antibody delivery reagent. This lipid-based formulation is the first serum compatible reagent allowing the delivery of functional antibodies into living cells.

Due to itsunique properties, Ab-DeliverINTM forms non-covalent complexes with antibodiesthrough electrostatic and hydrophobic interactions. Consequently, chemical orgenetic couplings are not necessary. In addition, delivered antibodies retaintheir structure and function. This feature makes Ab-DeliverINTM an exclusivereagent allowing the antibody to reach its intracellular target.

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Ab-DeliverIN^TM opens new fields of investigation in proteomics to elucidate complex molecularmechanisms or to design new potential therapies. For example, the intracellulardelivery of blocking antibodies could inhibit and/or neutralize proteinfunction.  

• Functionally active antibodies delivery

• Highly efficient in many primary cells and cell lines

• Serum compatible

• Biodegradable and no cytotoxicity

• Easy: straightforward protocol and ready-to-use

Intracellularlocalization of functional antibody

Ab-DeliverIN^TM permits the delivery of a functional antibody, making possible intracellularstaining and protein localization studies.

Anti-giantin and anti-NPC antibodies localization

Highlyefficient antibody transfection

Ab-DeliverIN^TM permits the delivery of antibodies in a large number of cells. It has beensuccessfully tested on a large range of immortalized and primary cellsincluding primary neurons and glial cells.

Delivery of antibodies in HEK cells and L929 fibroblasts

Delivery reagents comparison

Incomparison with other protein delivery systems, Ab-DeliverIN^TM demonstrateshigher delivery efficiency inside living cells.

Anti-NPC and non specific FITC-IgG delivery comparison

Serumcompatible and fast delivery

Ab-deliverIN^TM is fully biodegradable and does not interfere with cellular mechanisms. Inaddition, it is compatible with serum containing culture media. You can obtaina significant amount of antibodies transported with no medium change which isless stressful for your cells. In vitroand in vivo experiments can bedirectly and quickly accomplished. Highest efficiencies can be achieved in lessthan 5 hours.

Delivery of proteins inside cells in presence of serum

Rapidand easy-to-use antibody transfection reagent

1. Mix Ab-DeliverIN^TM and antibodies
2. Incubate 10 min at room temperature
3. Add onto cells and incubate under standard conditions

Each kit contains 10 µg of FITC-labeled IgG at a concentration of 100 µg / mL in PBS.