OZB Highlights

June 2011 - Volume 3 - Number 2

Gene Silencing: Success stories

Gene knockdown in hESC (Human Embryonic Stem Cells) with Lullaby®

A. Barroso-delJesus et al. The Nodal inhibitor Lefty is negatively modulated by the
microRNA miR-302 in human embryonic stem cells.
FASEB J. 2011 May; 25(5):1497-508

siRNA delivery into monocyte-derived macrophages with SilenceMag

Kadiu et al. Macrophage endocytic trafficking of antiretroviral nanoparticles.
Nanomedicine, 2011 Mar 21. [Epub ahead of print].

Gene silencing in hippocampal neurons cells using SilenceMag transfection reagent

J.C Gant et al. Disrupting function of FK506-binding protein 1b/12.6 induces the
Ca²+-dysregulation aging phenotype in hippocampal neurons.
J Neurosci. 2011 Feb 2;31(5):1693-703

 Scientific Newsletter June 2011

Previous Newsletters:

March 2011 - Volume 3 - Number 1

Efficient production of stably transfected Fibroblast expressing WRN gene with DreamFect™ reagent

Ammazzalorso et al. ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
The EMBO Journal 2010; 29:3156 - 3169. 

COX-2 gene silencing in MC3T3-E1 cells using SilenceMag transfection reagent

F. Zhang et al. Interleukin-17A induces cathepsin K and MMP-9 expression in osteoclasts via celecoxib-blocked prostaglandin E2 in osteoblasts.
Biochimie 2011; 93(2):296-305 

Efficient delivery of anti-ricin antibody with Ab-DeliverINTM in RAW264.7 cells

F.Wu et al. Protective effects of anti-ricin A-chain antibodies delivered intracellularly against ricin-induced cytotoxicity.
World J Biol Chem 2010; 1:188-195