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Glioma-induced DNMT3A reduction in microglia promotes an anti-tumoral phenotype
Authors: Cheray, M., Posada-Pérez, M., Fragkopoulou, A. et al. Source: Cell Death Differ (2026). They discovered that a transient reduction in DNA methylation... -
CRISPR-based functional genomics in primary acute myeloid leukemia samples
Authors: Cao Z, Yu S, Peng J et al. Source: Molecular Cell. They developed an optimized CRISPR-based platform for functional genomics in patient-derived xenograft (PDX)... -
Enhancing transduction efficiency of lentiviral vectors in CAR-T cell therapy
Authors: Ferreira R et al. Source: Front. Med. The stepwise optimization developed in this study brought transduction efficiency of the anti-FITC-CAR construct from an average of ~1% to ~50%
