Lipid NanoParticles (LNP)

Lipid Nanoparticles (LNP): A Revolutionary Delivery System for RNA Therapeutics

The RNA therapeutics have the potential to revolutionize medicinal fields as they are safe, easy to reproduce (e.g. IVT) and offer a great deal of versatility.

Naked mRNA therapeutics are generally unstable. They require high doses and show low permeability to cell membranes. Drug delivery systems are necessary to deliver mRNA for in vitro, pre-clinical and clinical applications. For this purpose, OZ Biosciences provides portfolio & custom lipid nanoparticles (LNP) delivery systems.

To date, formulation in LNP represents the most advanced non-viral delivery platform for nucleic acid therapy and promising candidates to treat manifold diseases.

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About NanOZ-LNPs

LNPs are liposome-like structures, engineered for encapsulating a broad variety of nucleic acids (RNA, mRNA, siRNA, gRNA, cRNA and DNA) and APIs; LNPs consist in an aqueous core surrounded by a lipidic shell based on a combination of 4 families of chemicals, each having distinct functions (Fig.1). 

Figure 1. Schematic representation of lipid nanoparticles (LNPs) composed by a mixture of four lipidic family, usually: complexing lipid, helper phospholipid, cholesterol and stealth-lipid at defined ratio to potentiate nucleic acid activity.

In the last 20 years, OZ Biosciences has developed strong expertise in aminated lipids, which allowed the screening of several tens formulations in order to develop optimized OZ Biosciences LNPs referred as NanOZ-LNP. These proprietary lipids are protected by patents and available for licensing.

LNP/RNA systems self-assemble via electrostatic interactions between negatively charged RNA and ionizable cationic lipids. Our LNPs are produced through microfluidic technology, resulting in monodisperse nanoparticles with narrow size distribution and high encapsulation efficiency.

NanOZ-LNP have been designed as safe and advanced nanomaterials to potentiate nucleic acids/APIs activity through their effective encapsulation and delivery of payload to specific cell types and tissues.

Currently, LNPs hold great potential in diverse pharmaceutical applications including oncology, immunotherapy, regenerative medicine and chronic diseases treatment.

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Technical Resources

• LNP Stability Note - Download
• White Paper: Ionizable lipids for mRNA-LNP and siRNA-LNP - Download
• LNP F.A.Q- Read